Adults requiring cord blood transplants but have insufficient cell doses from a single cord blood unit can receive two units with successful engraftment kinetics similar to those of children receiving a single unit

Gal Goldstein*, Ronit Elhasid, Bella Bielorai, Avichai Shimoni, Ronit Yerushalmi, Imad Kassis, Arnon Nagler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We retrospectively evaluated neutrophil engraftment kinetics in 29 single versus nine double unit cord blood transplants (CBTs). All single CBTs were performed in pediatric patients (non-malignant/malignant diseases, 19/10), while all double CBTs were performed in adults (n = 8) and an adolescent (n = 1) with hematological malignancies. Median follow-up time was 2.3 years (range, 0.1-13.5 years). Engraftment was achieved in 69% and 89% of the single and double cord blood (CB) groups, respectively. Similarly, median day of engraftment was not different for the single versus the double CBTs, at 19 and 23 days, respectively, and the neutrophil engraftment kinetics was similar in the two groups. Our data indicate that adults without sufficient nucleated cell doses in a single CB unit may receive two units with similar engraftment kinetics to those of children receiving only a single unit.

Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalLeukemia and Lymphoma
Volume52
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • Cord blood (CB)
  • double cord blood units
  • engraftment kinetics
  • stem cell transplant

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