TY - JOUR
T1 - Adults requiring cord blood transplants but have insufficient cell doses from a single cord blood unit can receive two units with successful engraftment kinetics similar to those of children receiving a single unit
AU - Goldstein, Gal
AU - Elhasid, Ronit
AU - Bielorai, Bella
AU - Shimoni, Avichai
AU - Yerushalmi, Ronit
AU - Kassis, Imad
AU - Nagler, Arnon
PY - 2011/4
Y1 - 2011/4
N2 - We retrospectively evaluated neutrophil engraftment kinetics in 29 single versus nine double unit cord blood transplants (CBTs). All single CBTs were performed in pediatric patients (non-malignant/malignant diseases, 19/10), while all double CBTs were performed in adults (n = 8) and an adolescent (n = 1) with hematological malignancies. Median follow-up time was 2.3 years (range, 0.1-13.5 years). Engraftment was achieved in 69% and 89% of the single and double cord blood (CB) groups, respectively. Similarly, median day of engraftment was not different for the single versus the double CBTs, at 19 and 23 days, respectively, and the neutrophil engraftment kinetics was similar in the two groups. Our data indicate that adults without sufficient nucleated cell doses in a single CB unit may receive two units with similar engraftment kinetics to those of children receiving only a single unit.
AB - We retrospectively evaluated neutrophil engraftment kinetics in 29 single versus nine double unit cord blood transplants (CBTs). All single CBTs were performed in pediatric patients (non-malignant/malignant diseases, 19/10), while all double CBTs were performed in adults (n = 8) and an adolescent (n = 1) with hematological malignancies. Median follow-up time was 2.3 years (range, 0.1-13.5 years). Engraftment was achieved in 69% and 89% of the single and double cord blood (CB) groups, respectively. Similarly, median day of engraftment was not different for the single versus the double CBTs, at 19 and 23 days, respectively, and the neutrophil engraftment kinetics was similar in the two groups. Our data indicate that adults without sufficient nucleated cell doses in a single CB unit may receive two units with similar engraftment kinetics to those of children receiving only a single unit.
KW - Cord blood (CB)
KW - double cord blood units
KW - engraftment kinetics
KW - stem cell transplant
UR - http://www.scopus.com/inward/record.url?scp=79953208286&partnerID=8YFLogxK
U2 - 10.3109/10428194.2010.548109
DO - 10.3109/10428194.2010.548109
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C2 - 21338286
AN - SCOPUS:79953208286
SN - 1042-8194
VL - 52
SP - 635
EP - 641
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 4
ER -