TY - JOUR
T1 - Adult-onset temporal lobe epilepsy, cognitive decline, multi-antiepileptic drug hypersensitivity, and Hashimoto's encephalopathy
T2 - Two case studies
AU - Sadan, Ofer
AU - Seyman, Estelle
AU - Ash, Elissa L.
AU - Kipervasser, Svetlana
AU - Neufeld, Miri Y.
PY - 2013/8
Y1 - 2013/8
N2 - Hashimoto's encephalopathy is defined by the coexistence of encephalopathy and antithyroid antibodies. We report two cases of adult-onset temporal lobe epilepsy with subacute cognitive decline, high titers of antithyroid antibodies, multi-antiepileptic drug hypersensitivity, and good response to immunomodulatory treatment. The relevance of multidrug hypersensitivity in the setting of adult-onset epilepsy and the importance of searching for autoimmune causes for epilepsy are discussed.
AB - Hashimoto's encephalopathy is defined by the coexistence of encephalopathy and antithyroid antibodies. We report two cases of adult-onset temporal lobe epilepsy with subacute cognitive decline, high titers of antithyroid antibodies, multi-antiepileptic drug hypersensitivity, and good response to immunomodulatory treatment. The relevance of multidrug hypersensitivity in the setting of adult-onset epilepsy and the importance of searching for autoimmune causes for epilepsy are discussed.
KW - AED
KW - Hashimoto's encephalopathy
KW - Hypersensitivity
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=84883535443&partnerID=8YFLogxK
U2 - 10.1016/j.ebcr.2013.07.004
DO - 10.1016/j.ebcr.2013.07.004
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:84883535443
SN - 2213-3232
VL - 1
SP - 132
EP - 135
JO - Epilepsy and Behavior Case Reports
JF - Epilepsy and Behavior Case Reports
IS - 1
ER -