Adult metachromatic leukodystrophy with an unusual relapsing - Remitting course

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Abstract

A 46 year old woman had a relapsing-remitting course of hemiparesis, disorientation, paraparesis and seizures, followed by progressive dementia, spasticity and ataxia. Computed tomography at onset showed a parietotemporal hypodense area with diffuse mottled enhancement obliterating the lateral ventricle. Subsequent scans demonstrated symmetric periventricular non-enhancing hypodensities, progressive ventricular enlargement and atrophy. Adult metachromatic leukodystrophy was diagnosed on the basis of low leukocyte arylsulphatase A level and metachromatic material accumulation at neural nerve biopsy.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
JournalPostgraduate Medical Journal
Volume68
Issue number797
DOIs
StatePublished - 1992
Externally publishedYes

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