Adrenocorticotropic hormone gel for patients with non-infectious uveitis

Yael Sharon*, David S. Chu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To describe the potential role of adrenocorticotropic hormone (ACTH) gel treatment in patients with chronic non-infectious uveitis. Observations: We report the clinical course of three patients with bilateral, non-infectious anterior and intermediate uveitis, treated with ACTH gel for ≥12 months. All three patients had chronic and steroid-dependent ocular inflammation with subsequent development of ocular complications. Twice-weekly treatment with subcutaneous 80 unit/day ACTH gel was administered, and clinical outcome measures were observed. After a mean period of 14 months, all patients demonstrated significant improvement in disease activity, stable visual acuity, and an absence of side effects. Systemic steroids dosage was successfully reduced from a mean dose of 16 mg/day upon the initiation of ACTH gel treatment to 2 mg/day at last follow up. Conclusions and Importance: Subcutaneous ACTH gel has shown to be a safe and effective therapy in the management of non-infectious uveitis. Specifically, ACTH gel plays a role in refractory and steroid-dependent cases and in those who do not respond to or are unable to tolerate other immunomodulatory therapies.

Original languageEnglish
Article number100502
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Sep 2019
Externally publishedYes


  • Adrenocorticotropic hormone
  • Chronic
  • Non-infectious
  • Uveitis


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