Adrenergic pupillary responses in the spontaneous hypertensive rat

A. Magor, S. Shavit, A. D. Korczyn

Research output: Contribution to journalArticlepeer-review

Abstract

The mydriatic effects of phenylephrine, cocaine and hydroxyamphetamine and the miotic effect of phentolamine were compared in spontaneous hypertensive rats (SHR) and normotensive Wistar Kyoto rats at various ages (3-20 weeks). Drugs were given as eye drops. The responses of SHR were significantly lower to the direct adrenergic agonist phenylephrine and higher to the indirect sympathomimetic amines cocaine and hydroxyamphetamine. The miotic effect of phentolamine was also more pronounced in SHR. The results suggest elevated norepinephrine release in SHR with subsensitivity of the radial smooth muscle of the iris to alpha-adrenergic agonists, possible as a compensatory mechanism.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalBiogenic Amines
Volume6
Issue number2
StatePublished - 1989

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