ADP/ATP translocator is essential only for anaerobic growth of yeast Saccharomyces cerevisiae

T. Drgoň, L. Šabová, N. Nelson, J. Kolarov

Research output: Contribution to journalArticlepeer-review

Abstract

All three genes (AAC1,AAC2 and AAC3) encoding the mitochondrial ADP/ATP translocator, were inactivated in a haploid yeast strain by a gene disruption technique. The triple mutant was still able to grow on fermentable carbon sources but only in the presence of oxygen. Under aerobic conditions neither translocator-protein nor carrier-mediated transport was detected in all mutants in which the AAC2 gene was disrupted. It was further shown that a functional AAC genes product is essential only for anaerobic growth of Saccharomyces cerevisiae but not for growth under derepressed conditions. Under anaerobic conditions a non-detectable amount of AAC3 gene product is sufficient to ensure the cell growth and multiplication.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalFEBS Letters
Volume289
Issue number2
DOIs
StatePublished - 9 Sep 1991
Externally publishedYes

Keywords

  • ADP/ATP translocator
  • Gene disruption
  • Mitochondrion
  • Yeast

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