TY - JOUR
T1 - ADNP regulates cognition
T2 - A multitasking protein
AU - Gozes, Illana
N1 - Publisher Copyright:
© 2007 - 2018 Frontiers Media S.A.
PY - 2018/11/26
Y1 - 2018/11/26
N2 - Introduction With the advantage of rapid progress of DNA/RNA sequencing techniques, it has become feasible to identify the cause of developmental disorders encompassing intellectual disabilities to single de novo mutated genes (e.g., Larsen et al., 2016; Deciphering Developmental Disorders, 2017; Stessman et al., 2017). It is my opinion that we should study in depth, the leading identified genes, to acquire better understanding of the molecular basis for human cognitive functions. Furthermore, from a translational science point of view, understanding genes regulating cognition will facilitate drug development to currently untreatable devastating disease, which hamper cognition. Here, I focus on activity-dependent neuroprotective protein (ADNP) (Gozes et al., 2018) showing a tight association with cognition, and in my opinion, a key gene regulating cognitive functions.
AB - Introduction With the advantage of rapid progress of DNA/RNA sequencing techniques, it has become feasible to identify the cause of developmental disorders encompassing intellectual disabilities to single de novo mutated genes (e.g., Larsen et al., 2016; Deciphering Developmental Disorders, 2017; Stessman et al., 2017). It is my opinion that we should study in depth, the leading identified genes, to acquire better understanding of the molecular basis for human cognitive functions. Furthermore, from a translational science point of view, understanding genes regulating cognition will facilitate drug development to currently untreatable devastating disease, which hamper cognition. Here, I focus on activity-dependent neuroprotective protein (ADNP) (Gozes et al., 2018) showing a tight association with cognition, and in my opinion, a key gene regulating cognitive functions.
KW - ADNP (activity dependent neuroprotective protein)
KW - ADNP gene
KW - Cognition
KW - Neurodegenaration
KW - Protein interaction
UR - http://www.scopus.com/inward/record.url?scp=85057724946&partnerID=8YFLogxK
U2 - 10.3389/fnins.2018.00873
DO - 10.3389/fnins.2018.00873
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AN - SCOPUS:85057724946
SN - 1662-4548
VL - 12
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
IS - NOV
M1 - 873
ER -