TY - JOUR
T1 - ADNP Plays a Key Role in Autophagy
T2 - From Autism to Schizophrenia and Alzheimer's Disease
AU - Sragovich, Shlomo
AU - Merenlender-Wagner, Avia
AU - Gozes, Illana
N1 - Publisher Copyright:
© 2017 WILEY Periodicals, Inc.
PY - 2017/11
Y1 - 2017/11
N2 - Activity-dependent neuroprotective protein (ADNP), discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome (Helsmoortel-Van Der Aa). One of the most important cellular processes associated with ADNP is the autophagy pathway, recently discovered by us as a key player in the pathophysiology of schizophrenia. In this regard, given the link between the microtubule and autophagy systems, the ADNP microtubule end binding protein motif, namely, the neuroprotective NAP (NAPVSIPQ), was found to enhance autophagy while protecting microtubules and augmenting ADNP's association with both systems. Thus, linking autophagy and ADNP is proposed as a major target for intervention in brain diseases from autism to Alzheimer's disease (AD) and our findings introduce autophagy as a possible novel target for treating schizophrenia.
AB - Activity-dependent neuroprotective protein (ADNP), discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome (Helsmoortel-Van Der Aa). One of the most important cellular processes associated with ADNP is the autophagy pathway, recently discovered by us as a key player in the pathophysiology of schizophrenia. In this regard, given the link between the microtubule and autophagy systems, the ADNP microtubule end binding protein motif, namely, the neuroprotective NAP (NAPVSIPQ), was found to enhance autophagy while protecting microtubules and augmenting ADNP's association with both systems. Thus, linking autophagy and ADNP is proposed as a major target for intervention in brain diseases from autism to Alzheimer's disease (AD) and our findings introduce autophagy as a possible novel target for treating schizophrenia.
KW - ADNP
KW - NAP
KW - autism
KW - autophagy
KW - schizophrenia
KW - sexual divergence
UR - http://www.scopus.com/inward/record.url?scp=85030263400&partnerID=8YFLogxK
U2 - 10.1002/bies.201700054
DO - 10.1002/bies.201700054
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AN - SCOPUS:85030263400
SN - 0265-9247
VL - 39
JO - BioEssays
JF - BioEssays
IS - 11
M1 - 1700054
ER -