TY - JOUR
T1 - Administration, distribution, metabolism and elimination of polymer therapeutics
AU - Markovsky, Ela
AU - Baabur-Cohen, Hemda
AU - Eldar-Boock, Anat
AU - Omer, Liora
AU - Tiram, Galia
AU - Ferber, Shiran
AU - Ofek, Paula
AU - Polyak, Dina
AU - Scomparin, Anna
AU - Satchi-Fainaro, Ronit
N1 - Funding Information:
The Satchi-Fainaro laboratory is supported by Grant No. 5145-300000 from the Chief Scientist Office of the Ministry of Health, Israel , by the Israel Science Foundation (Grant No. 1309/10 ), a grant from the Alon Foundation , the Israel Cancer Association , Grant No. 2007347 given by the United States–Israel Binational Science Foundation (BSF) , the German–Israel Foundation (GIF) , the Israel Cancer Research Fund (ICRF) , Association for International Cancer Research (AICR) , TAU Center for Nanoscience and Nanotechnology and the Swiss Bridge .
PY - 2012/7/20
Y1 - 2012/7/20
N2 - Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.
AB - Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.
KW - ADME
KW - Angiogenesis
KW - Angiogenesis- dependent diseases
KW - Biodistribution
KW - Cancer
KW - Polymer therapeutics
UR - http://www.scopus.com/inward/record.url?scp=84862675929&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2011.12.021
DO - 10.1016/j.jconrel.2011.12.021
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C2 - 22286005
AN - SCOPUS:84862675929
SN - 0168-3659
VL - 161
SP - 446
EP - 460
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -
