Administration, distribution, metabolism and elimination of polymer therapeutics

Ela Markovsky, Hemda Baabur-Cohen, Anat Eldar-Boock, Liora Omer, Galia Tiram, Shiran Ferber, Paula Ofek, Dina Polyak, Anna Scomparin, Ronit Satchi-Fainaro*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Polymer conjugation is an efficient approach to improve the delivery of drugs and biological agents, both by protecting the body from the drug (by improving biodistribution and reducing toxicity) and by protecting the drug from the body (by preventing degradation and enhancing cellular uptake). This review discusses the journey that polymer therapeutics make through the body, following the ADME (absorption, distribution, metabolism, excretion) concept. The biological factors and delivery system parameters that influence each stage of the process will be described, with examples illustrating the different solutions to the challenges of drug delivery systems in vivo.

Original languageEnglish
Pages (from-to)446-460
Number of pages15
JournalJournal of Controlled Release
Volume161
Issue number2
DOIs
StatePublished - 20 Jul 2012

Keywords

  • ADME
  • Angiogenesis
  • Angiogenesis- dependent diseases
  • Biodistribution
  • Cancer
  • Polymer therapeutics

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