Adjuvant treatment of early colon cancer with micrometastases: Results of a national survey

Scott S. Short, Alexander Stojadinovic, Aviram Nissan, Zev Wainberg, Deepti Dhall, Kathy Yao, Anton Bilchik

Research output: Contribution to journalReview articlepeer-review


Background and Objectives: Optimal adjuvant treatment for patients with Stage I/II colon cancer with micrometastases (MM) is unknown. Because there is no known adjuvant treatment-related benefit, we evaluated whether MM influenced treatment decisions. Method: Review of a national survey from members of the SSO and ASCO. Results: Of 602 survey responses, 305 (51%) stated that MM had significant prognostic value, 250 (42%) were unsure, and 47 (7%) did not believe that MM held prognostic value. Three hundred seventy-four (63%) would offer adjuvant therapy in the setting of MM, while 222 (37%) would not. Only 15% routinely performed IHC on lymph nodes. Medical oncologists were more likely to recommend adjuvant therapy compared to surgical oncologists (68% vs. 51%, P = 0.001). Conclusions: MM in colon cancer apparently influenced adjuvant treatment decisions absent known prognostic benefit. Prospective trials are needed to improve the selection of patients for systemic chemotherapy in early, node-negative colon cancer.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalJournal of Surgical Oncology
Issue number2
StatePublished - 1 Aug 2012
Externally publishedYes


  • adjuvant chemotherapy
  • colon cancer
  • lymph node metastases
  • micrometastatic disease


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