Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance

Yonit Marcus; Gabi Shefer; Naftali Stern

doi:10.1016/j.mce.2012.06.021

Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance

Yonit Marcus, Gabi Shefer, Naftali Stern^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

This review focuses on the expression of the key components of the renin-angiotensin-aldosterone axis in fat tissue. At the center of this report is the role of RAAS in normal and excessive fat mass enlargement, the leading etiology of insulin resistance. Understanding the expression and regulation of RAAS components in various fat depots allows insight not only into the processes by which these complex patterns are modified by the enlargement of adipose tissue, but also into their impact on local and systemic response to insulin.

Original language	English
Pages (from-to)	1-14
Number of pages	14
Journal	Molecular and Cellular Endocrinology
Volume	378
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2012.06.021
State	Published - 25 Sep 2013

Keywords

Adipocytes
Hypertension
Inflammation
Obesity
Type 2 diabetes
Visceral fat

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mce.2012.06.021

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Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance

Abstract

Keywords

UN SDGs

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