Adiponectin and leptin concentrations in dichorionic twins with discordant and concordant growth

Shali Mazaki-Tovi, Hannah Kanety, Clara Pariente, Rina Hemi, Yoav Yinon, Amir Wiser, Eyal Schiff, Eyal Sivan

Research output: Contribution to journalArticlepeer-review


Context: Discordant twin gestation, in which one fetus is growth restricted, is a unique model that can elucidate the mechanism(s) by which the intrauterine environment affects fetal growth.Objective: The objective of the study was to determine the cord blood adiponectin and leptin concentrations and evaluate their association with birth weight in dichorionic twins, with and without growth discordance.Design, Setting, Participants, and Main Outcome Measure: In this cross-sectional study, arterial cord blood adiponectin and leptin concentrations were determined in two groups of newborns: 1) discordant twins, in which one of the twins is growth restricted (small for gestation age and abnormal umbilical arteries Doppler) and the other is appropriate for gestation age (AGA) (n = 14 pairs); and 2) concordant twins, in which both twins are AGA (n = 15 pairs).Results: Results were: 1) within the discordant twins group, the median adiponectin concentration was significantly lower in the growth-restricted newborns than in their cotwins (P = 0.004); 2) within the concordant twin group, there was no significant difference in the median cord blood adiponectin concentration between the two AGA twins; 3) the median leptin concentration did not differ between the twins pairs in both study groups; 4) a positive correlation between cord blood adiponectin concentrations and both birth weight (r = 0.7, P <0.001) and gestational age (r = 0.6, P <0.02) was found only in the small-for-gestational-age newborns; 5) linear regression model revealed that birth weight is independently associated with circulating adiponectin concentration.Conclusions: Low circulating adiponectin concentrations, previously reported in adults, children, and infants who were born small for gestational age, characterize fetuses with growth restriction and are independently associated with birth weight.

Original languageEnglish
Pages (from-to)892-898
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Mar 2009


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