Adhesive microbeads for the targeting delivery of anticaries agents of vegetable origin

Bice Conti*, Barbara Colzani, Adele Papetti, Dora Mascherpa, Rossella Dorati, Ida Genta, Carla Pruzzo, Caterina Signoretto, Edjia Zaura, Peter Lingström, Itzak Ofek, Mike Wilson, David A. Spratt, Gabriella Gazzani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The formulation of quinic acid, a food constituent demonstrating potential anticaries and antigingivitis properties, was investigated in an adhesive microparticulate delivery system with the goal of improving its effect by prolonging its residence time at the site of action. Alginate and chitosan were selected as mucoadhesive polymers. The microspheres were prepared by coacervation. Different types of alginates, polymers blends and crosslinking agent concentrations were considered and evaluated. The best results in terms of encapsulation efficiency, in vitro active agent release profile and in vitro adhesive properties, both to oral mucosa and to teeth surface, were obtained with a blend of Alginate Protanal LF200S: Alginate Protanal LF120LS 1:1.5 w/w, 0.1 M CaCl2, and chitosan coating, prepared by a one-step complex coacervation method. This microparticulate delivery system showed prolonged release of quinic acid, and could be used as an active component in chewing gums or mouthwashes for both caries and gingivitis prevention.

Original languageEnglish
Pages (from-to)898-904
Number of pages7
JournalFood Chemistry
Issue number2-3
StatePublished - 1 Jun 2013


  • Alginate
  • Anticaries
  • Antigingivitis
  • Bioadhesion
  • Chitosan
  • Functional foods
  • Microparticles


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