Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize

Alexander Bershadsky*, Michael Kozlov, Benjamin Geiger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Adhesion-mediated signaling provides cells with information about multiple parameters of their microenvironment, including mechanical characteristics. Often, such signaling is based on a unique feature of adhesion structures: their ability to grow and strengthen when force is applied to them, either from within the cell or from the outside. Such adhesion reinforcement is characteristic of integrin-mediated cell-matrix adhesions, but may also operate in other types of adhesion structures. Though the amount of knowledge about adhesion-mediated signaling is growing rapidly, the mechanisms underlying force-dependent regulation of junction assembly are largely unknown. Experiments have been carried out that have started to uncover the major signaling pathways involved in the response of adhesion sites to force. Theoretical models have also been used to address the physical mechanisms underlying adhesion-mediated mechanosensing.

Original languageEnglish
Pages (from-to)472-481
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume18
Issue number5
DOIs
StatePublished - Oct 2006

Funding

FundersFunder number
Marie Curie Network
Pasteur-Weizmann Council
National Institutes of Health
National Institute of General Medical SciencesU54GM064346
United States - Israel Binational Science Foundation
United States-Israel Binational Science Foundation
Israel Science Foundation

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