Adherence with oseltamivir chemoprophylaxis among workers exposed to poultry during avian influenza outbreaks in southern Israel

Ilana Belmaker, Michael Lyandres, Natalya Bilenko, Larissa Dukhan, Ella Mendelson, Michal Mandelboim, Liora Shahar-Rotberg, Einat Bitran, Yochi Yossef, Itamar Grotto

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To determine adherence with recommended pre- and post-exposure oseltamivir prophylaxis (OP) among workers exposed to poultry during five simultaneous avian influenza (AI) H5N1 outbreaks in poultry farms in southern Israel in March 2006, as well as the efficiency of the distribution system of oseltamivir in the community. Design: Epidemiological investigation identified 201 workers exposed to poultry during AI outbreaks. They were interviewed by a public health nurse regarding adherence with recommended OP, symptoms, and possible side effects. Data were collected on type of exposure, age, sex, rate of adherence with OP, and reasons for non-adherence. For eight workers, paired sera were drawn for the determination of antibodies to H5. Data were collected on the efficiency of the distribution of oseltamivir tablets to workers in the community. Results: High adherence with OP (87.6%) was found among poultry workers during outbreaks of AI, with no difference by type of exposure, age, or sex. There was a low rate of side effects of OP (1.5%). No exposed workers developed AI and none of the eight who had paired sera drawn showed seroconversion. The distribution of OP in the community was inefficient, with 27.7% of the tablets 'lost' or returned unusable. Conclusions: These data emphasize the importance of developing efficient targeted distribution systems in the community for OP, in order to prevent human infection during AI outbreaks.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalInternational Journal of Infectious Diseases
Volume13
Issue number2
DOIs
StatePublished - Mar 2009
Externally publishedYes

Keywords

  • Adherence
  • Avian influenza
  • Oseltamivir prophylaxis
  • Outbreak
  • Side effects

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