Additive contribution of DRD3gly and HT2CRser alleles to susceptibility to tardive dyskinesia in patients with chronic schizophrenia

R. H. Segman*, U. Levy, B. Finkel, D. Greenberg, A. Lerner, A. Yakir, M. Shlaffman, A. Dorevich, A. Shelevoy, B. Lerer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We previously reported an excess of the dopamine D3 receptor glycine allele (DRD3gly) and of DRD3ser-gly and DRD3gly-gly genotypes in 53 chronic schizophrenia patients with tardive dyskinesia (TD) who were on a stable antipsychotic dose and were matched to 63 schizophrenia patients without TD (Segman et al., Mol Psychiatry, 4:247-253, 1999). We genotyped the same group of patients for a functionally relevant cysteine to serine polymorphism in the 5-HT2C receptor gene (HT2CR). There was an excess of HT2CRser alleles in the patients with TD (27.1% vs. 14.6%, p=.04). By ANCOVA (controlling for age at first antipsychotic treatment), there was a significant effect of HT2CR genotype on AIMS orofacial dyskinesia (AIMSOFD) scores (F=3.47, df 2, p=.03). In a further ANCOVA in which the independent variables were carriage of DRD3gly or HT2CR-ser alleles, there was a significant main effect of both alleles on AIMS-OFD scores (p=.006 and p=.02) but no interaction. In a stepwise multiple regression, 8.2% of the variance in AIMS-OFD scores was accounted for by age at first antipsychotic treatment (p=.0001), 3.7% by gender (p=.02), 4.6% by DRD3gly (p=.02) and 4.2% by HT2CRser (p=.001). These findings support an additive contribution of DRD3gly and HT2CRser alleles to the complex TD phenotype.

Original languageEnglish
Pages (from-to)529-530
Number of pages2
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume96
Issue number4
StatePublished - 7 Aug 2000
Externally publishedYes

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