Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: A randomized prospective study

A. Wiser*, O. Gonen, Y. Ghetler, T. Shavit, A. Berkovitz, A. Shulman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

BACKROUND: The aim of this study was to evaluate the effect of dehydroepiandrosterone (DHEA) supplementation on in vitro fertilization (IVF) data and outcomes among poor-responder patients. METHODS: A randomized, prospective, controlled study was conducted. All patients received the long-protocol IVF. Those in the study group received 75 mg of DHEA once a day before starting the next IVF cycle and during treatment. RESULTS: Thirty-three women with significantly diminished ovarian reserves were enrolled, 17 in the DHEA group and 16 in the control group. The 33 patients underwent 51 IVF cycles. The DHEA group demonstrated a non-significant improvement in estradiol levels on day of hCG (P = 0.09) and improved embryo quality during treatment (P = 0.04) between first and second cycles. Patients in the DHEA group also had a significantly higher live birth rate compared with controls (23.1 versus 4.0; P = 0.05), respectively. Six of seven deliveries were among patients with secondary infertility (P = 0.006). CONCLUSION Dehydroepiandrosterone supplementation can have a beneficial effect on ovarian reserves for poor-responder patients on IVF treatment.

Original languageEnglish
Pages (from-to)2496-2500
Number of pages5
JournalHuman Reproduction
Volume25
Issue number10
DOIs
StatePublished - Oct 2010

Keywords

  • DHEA
  • Dehydroepiandrosterone
  • IVF outcome
  • long-protocol IVF
  • poor responder
  • recombinant LH

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