@article{ece91482f4f84c6896bfdcbd2990cebc,
title = "Adding to the CASeload: unwarranted p53 signaling induced by Cas9",
abstract = "We investigated the genetic and transcriptional changes associated with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated protein 9 (Cas9) expression in human cancer cell lines. For a subset of cell lines with a wild-type tumor protein TP53 (best known as p53), we detected p53 pathway activation, DNA damage accumulation and emerging p53-inactivating mutations following Cas9 introduction. We discuss the potential implications of our findings in basic and translational research.",
keywords = "CRISPR, Cas9, DNA damage response, TP53 mutation, genome editing, p53 pathway",
author = "Veronica Rendo and Enache, {Oana M.} and Uri Ben-David",
note = "Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 Taylor & Francis Group, LLC.",
year = "2020",
doi = "10.1080/23723556.2020.1789419",
language = "אנגלית",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
}
