Added Value of Fetal MRI in the Evaluation of Fetal Anomalies of the Corpus Callosum: A Retrospective Analysis of 78 Cases

Mirra Manevich-Mazor*, Alina Weissmann-Brenner, Omer Bar Yosef, Chen Hoffmann, Roei David Mazor, Mariela Mosheva, Reuven Ryszard Achiron, Eldad Katorza

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective To evaluate the added value of fetal MRI to ultrasound in detecting and specifying callosal anomalies, and its impact on clinical decision making. Methods Fetuses with a sonographic diagnosis of an anomalous corpus callosum (CC) who underwent a subsequent fetal brain MRI between 2010 and 2015 were retrospectively evaluated and classified according to the severity of the findings. The findings detected on ultrasound were compared to those detected on MRI. An analysis was performed to assess whether fetal MRI altered the group classification, and thus the management of these pregnancies. Results 78 women were recruited following sonographic diagnoses of either complete or partial callosal agenesis, short, thin or thick CC. Normal MRI studies were obtained inμ19 cases (24%). Among these, all children available for follow-up received an adequate adaptive score in their Vineland II adaptive behavior scale assessment. Analysis of the concordance between US and MRI demonstrated a substantial level of agreement for complete callosal agenesis (kappa: 0.742), moderate agreement for thin CC (kappa: 0.418) and fair agreement for all other callosal anomalies. Comparison between US and MRI-based mild/severe findings classifications revealed that MRI contributed to a change in the management for 28 fetuses (35.9%), mostly (25 fetuses, 32.1%) in favor of pregnancy preservation. Conclusion Fetal MRI effectively detects callosal anomalies and enables satisfactory validation of the presence or absence of callosal anomalies identified by ultrasound and adds valuable data that improves clinical decision making.

Original languageEnglish
Pages (from-to)513-525
Number of pages13
JournalUltraschall in der Medizin
Issue number5
StatePublished - 7 Jun 2018
Externally publishedYes


  • CNS anomalies
  • corpus callosum
  • fetal MRI
  • fetal ultrasound
  • pregnancy management


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