Acyclic and cyclic thioenamino peptides: solution- and solid-phase synthesis

Lee Goren, Doron Pappo, Israel Goldberg, Yoel Kashman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Seven- and 10-membered cyclic thioenamino peptides, that is, 1,4-thiazepinone (11) and cyclic thioenamino peptide 9 (which represents a potential γ-turn mimetic), were synthesized, and the structure of 11 was secured by X-ray diffraction analysis of its TFA salt. The aforementioned compounds were prepared in solution and by solid-phase synthesis. Additionally, we have prepared thioenamino diketopiperazine synthon 16.

Original languageEnglish
Pages (from-to)1048-1050
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number9
DOIs
StatePublished - 4 Mar 2009

Funding

FundersFunder number
Israeli Science Foundation180/05
Maiman Institute for Proteome Research
Tel Aviv University

    Keywords

    • Cyclic peptides
    • Endiamine
    • FGly
    • Solid-phase synthesis
    • Thioenamine

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