Acute tolerance to the excitatory effect of enkephalin microinjections into hippocampus

Zeev Elazar; Elias Motles; Yona Ely; Rabi Simantov

doi:10.1016/0024-3205(79)90176-0

Acute tolerance to the excitatory effect of enkephalin microinjections into hippocampus

Zeev Elazar^*
, Elias Motles
, Yona Ely
, Rabi Simantov

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Microinjections of 1-20 μg of leu-enkephalin were done in the dorsal hippocampus of cats and rats in acute experiments. Long lasting epileptiform changes in the hippocampal EEG were produced. These changes were prevented by previous microinjections of naloxone at the same site. When repeated microinjections of the same dose of enkephalin which initially was epileptogenic were done a progressive loss of effectiveness of the drug was observed. Also, progressively higher doses of enkephalin were necessary to produce effects comparable to the effect of the initial injection. These results suggest that acute tolerance may develop to the epileptogenic effect of leu-enkephalin in hippocampus.

Original language	English
Pages (from-to)	541-548
Number of pages	8
Journal	Life Sciences
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(79)90176-0
State	Published - 5 Feb 1979

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abstract = "Microinjections of 1-20 μg of leu-enkephalin were done in the dorsal hippocampus of cats and rats in acute experiments. Long lasting epileptiform changes in the hippocampal EEG were produced. These changes were prevented by previous microinjections of naloxone at the same site. When repeated microinjections of the same dose of enkephalin which initially was epileptogenic were done a progressive loss of effectiveness of the drug was observed. Also, progressively higher doses of enkephalin were necessary to produce effects comparable to the effect of the initial injection. These results suggest that acute tolerance may develop to the epileptogenic effect of leu-enkephalin in hippocampus.",

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AU - Elazar, Zeev

AU - Motles, Elias

AU - Ely, Yona

AU - Simantov, Rabi

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Y1 - 1979/2/5

N2 - Microinjections of 1-20 μg of leu-enkephalin were done in the dorsal hippocampus of cats and rats in acute experiments. Long lasting epileptiform changes in the hippocampal EEG were produced. These changes were prevented by previous microinjections of naloxone at the same site. When repeated microinjections of the same dose of enkephalin which initially was epileptogenic were done a progressive loss of effectiveness of the drug was observed. Also, progressively higher doses of enkephalin were necessary to produce effects comparable to the effect of the initial injection. These results suggest that acute tolerance may develop to the epileptogenic effect of leu-enkephalin in hippocampus.

AB - Microinjections of 1-20 μg of leu-enkephalin were done in the dorsal hippocampus of cats and rats in acute experiments. Long lasting epileptiform changes in the hippocampal EEG were produced. These changes were prevented by previous microinjections of naloxone at the same site. When repeated microinjections of the same dose of enkephalin which initially was epileptogenic were done a progressive loss of effectiveness of the drug was observed. Also, progressively higher doses of enkephalin were necessary to produce effects comparable to the effect of the initial injection. These results suggest that acute tolerance may develop to the epileptogenic effect of leu-enkephalin in hippocampus.

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Acute tolerance to the excitatory effect of enkephalin microinjections into hippocampus

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