1 A 38-year-old previously healthy worker accidentally spilled phenol-formaldehyde resin over a large area of his skin. 2 Several days later he was hospitalized with extensive necrotic skin lesions, fever, hypertension, adult respiratory distress syndrome (ARDS), proteinuria and renal functional impairment. 3 All symptoms improved progressively and eventually disappeared. 4 We propose that toxic materials originating from the necrotic skin lesions and the continued facilitated absorption of the resin and/or its components via the skin lesions were the main factors responsible for this alarming multisystem involvement. 5 Workers handling this material should be instructed to take appropriate precautions and physicians should be alerted to the potential pathophysiological consequences.