Acute-phase high-density lipoprotein in the rat does not contain serum amyloid A protein

M. L. Baltz, I. F. Rowe, D. Caspi, W. G. Turnell, M. B. Pepys

Research output: Contribution to journalArticlepeer-review

Abstract

Serum amyloid A protein (SAA) is an acute-phase apolipoprotein of high-density lipoprotein (HDL). Its N-terminal sequence is identical with that of amyloid A protein (AA), the subunit of AA amyloid fibrils. However, rats do not develop AA amyloidosis, and we report here that neither normal nor acute-phase rat HDL contains a protein corresponding to SAA of other species. mRNA coding for a sequence homologous with the C-terminal but not with the N-terminal part of human SAA is synthesized in greatly increased amounts in acute-phase rat liver. These observations indicate that the failure of rats to develop AA amyloid results from the absence of most of the AA-like part of their SAA-like protein, and that the N-terminal portion of SAA probably contains the lipid-binding sequences.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalBiochemical Journal
Volume242
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

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