TY - JOUR
T1 - Acute pancreatitis in rats
T2 - A 31P nuclear magnetic resonance study
AU - Kaplan, Ofer
AU - Kushnir, Tammar
AU - Sandbank, Uri
AU - Navon, Gil
N1 - Funding Information:
’ This work was supported in part by The Fund for Basic Research administered by The Israel Academy of Sciences and Humanities. It was presented in part at the Second Congress of European Society of Magnetic Resonance in Medicine and Biology, October 3-5, 1985. Montreux, Switzerland.
PY - 1987/8
Y1 - 1987/8
N2 - High resolution 31P nuclear magnetic resonance (NMR) was used to evaluate the severity of acute pancreatitis in rats. Experimental pancreatitis was induced by intraparenchymal injection of 10% sodium taurocholate. Pancreases were removed at various time periods and the NMR spectrum of the whole organ was recorded. Metabolic changes taking place during the progression of the disease were measured and correlated with the pathologic changes. Gradual depletion of the high energy compounds, adenosine triphosphate and phosphocreatine, was observed. The NMR spectral changes paralleled the extension of the pathologic lesions and were found to constitute a reliable indicator of the severity of acute pancreatitis. It is suggested that high resolution NMR may be used to evaluate the pathogenesis and therapy of various forms of experimental pancreatitis.
AB - High resolution 31P nuclear magnetic resonance (NMR) was used to evaluate the severity of acute pancreatitis in rats. Experimental pancreatitis was induced by intraparenchymal injection of 10% sodium taurocholate. Pancreases were removed at various time periods and the NMR spectrum of the whole organ was recorded. Metabolic changes taking place during the progression of the disease were measured and correlated with the pathologic changes. Gradual depletion of the high energy compounds, adenosine triphosphate and phosphocreatine, was observed. The NMR spectral changes paralleled the extension of the pathologic lesions and were found to constitute a reliable indicator of the severity of acute pancreatitis. It is suggested that high resolution NMR may be used to evaluate the pathogenesis and therapy of various forms of experimental pancreatitis.
UR - http://www.scopus.com/inward/record.url?scp=0023638072&partnerID=8YFLogxK
U2 - 10.1016/0022-4804(87)90161-2
DO - 10.1016/0022-4804(87)90161-2
M3 - מאמר
AN - SCOPUS:0023638072
VL - 43
SP - 172
EP - 178
JO - Journal of Surgical Research
JF - Journal of Surgical Research
SN - 0022-4804
IS - 2
ER -