Acute pancreatitis in children with inflammatory bowel disease: Risk factors, clinical course, and prognosis

Adi Anafy, Yehoshua Mirkin, Tut Galai, Amir Ben-Tov, Hadar Lev-Moran, Anat Yerushalmy-Feler, Shlomi Cohen, Achiya Z. Amir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: To characterize the clinical course of acute pancreatitis (AP) in pediatric inflammatory bowel disease (IBD) patients compared to children with AP without IBD and to identify risk factors associated with AP among IBD patients. Methods: This retrospective, single-center study compared clinical characteristics of children (<19 years) with AP with and without concomitant IBD who were hospitalized 2005–2019. We also conducted a risk factor analysis of AP development in pediatric IBD. Results: Sixty-eight (54% males) patients with 120 episodes of AP were admitted at a median age of 15.3 years. Thirteen patients (14 episodes) had a co-diagnosis of IBD, representing 4% of our IBD patient population. The AP-IBD patients presented with lower amylase levels compared to the non-IBD patients (160 [interquartile range, IQR: 83–231] vs. 418 [IQR: 176–874] U/L, p > 0.01), all had a mild pancreatitis, and none required invasive intervention. The presumed etiology for AP in all IBD patients was IBD-related: IBD flare-up in five, side effects of medications in two, and undetermined in seven. The only risk factor for AP development among IBD patients was IBD-associated arthritis (23% vs. 3% for IBD-non-AP, p = 0.04), while extracolonic Crohn's disease and induction therapy with nutrition were negative risk factors (15% vs. 51%, p = 0.05, and 8% vs. 44%, p = 0.04, respectively). Other parameters, including disease type and medications, were nonsignificant. Conclusion: The clinical course of AP in pediatric IBD patients is mild. Only IBD-associated arthritis emerged as a risk factor for the development of AP, while, unexpectedly, IBD medication did not.

Original languageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
StateAccepted/In press - 2024


  • Crohn's Disease
  • medication
  • pediatric
  • ulcerative colitis


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