Acute myocardial infarction severity, complications, and mortality associated with lack of magnesium intake through consumption of desalinated seawater

Meital Shlezinger, Yona Amitai, Ilan Goldenberg, Shaul Atar, Michael Shechter*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Drinking water (DW) is an important dietary source of magnesium. Israel has recently increased desalinated seawater (DSW) production for DW, but negligible magnesium content in DSW may pose a risk of hypomagnese-mia and consequential adverse cardiovascular effects. Consecutive acute myocardial infarction (AMI) patients (n = 380, age 35-75 years), hospitalized in 2015-2017 with ST-segment elevation myocardial infarction (STEMI), were divided into two groups based on their domicile region having a major supply of DSW (n = 250, 65%) or not (non-DSW; n = 130, 35%). We evaluated admission serum magnesium concentrations in patients, magnesium levels in tap water, 1-year all-cause mortality, and major adverse cardiovascular events (MACE), including all-cause mortality, nonfatal myocardial infarction, rehospitalization for heart failure or angina pectoris, stroke, coronary artery bypass grafting, and percutaneous coronary interventions. Multivariate analyses were adjusted for age and sex. Serum magnesium concentrations (mean� SD) were significantly higher among patients in the non-DSW group compared with the DSW group (1.95 0.20 mg/dL and 1.81� 0.20 mg/dL, P < 0.001; respectively). Additionally, the mean residential DW magnesium level in the DSW group was 5.4� 2.2 mg/L compared with 25.1 3.4 mg/L, P < 0.01 in the non-DSW group. Fewer patients (although not statistically significant) in the non-DSW group experienced major adverse cardiovascular events (MACE) or 1-year-all-cause mortality compared with the patients in the DSW group (12.4% and 20%, P = 0.065; respectively). In conclusion, in post AMI patients, we found non significant higher MACE and 1-year mortality with the use of DSW.

Original languageEnglish
Pages (from-to)39-50
Number of pages12
JournalMagnesium Research
Volume32
Issue number2
DOIs
StatePublished - 1 Apr 2019

Funding

FundersFunder number
Environment and Health FundPGA1403

    Keywords

    • Acute myocardial infarction
    • Cardiovascular
    • Desalinated seawater
    • Drinking water
    • Magnesium
    • Major adverse cardiovascular events

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