TY - JOUR
T1 - Acute lymphoblastic leukemia subtypes in israel
T2 - The sheba medical center experience
AU - Ramot, Bracha
AU - Ben-Bassat, Isaac
AU - Many, Amira
AU - Kende, George
AU - Neuman, Yoram
AU - Brok-Simoni, Frida
AU - Rosenthal, Esther
AU - Orgad, Shlomit
N1 - Funding Information:
Fifty-two ALL patients were diagnosed and treated between the years 1978 and the end of 1981. The following studies were done on blast ceils obtained either from the peripheral blood or bone marrow: E-rosette formation \[20\];s urface immunoglobulins using a directly fluoreseinated F(ab'h fragment; adenosine deaminase {ADA~ \[3J: nucleoside phosphorylase (NP) \[9\]:a s well as the standard staining reactions for PAS, peroxidase and acid phosphatase. From 1980 onwards the common ALL antigen (cALLA) was tested in a cytotoxicity *This study was supported by the Israel Cancer Association. +Holder of the Yechiel and Helen Lieber Chair for Cancer Research at the Tel-Aviv University, Tel-Aviv, Israel.
PY - 1982
Y1 - 1982
N2 - During the period from 1978 to 1981, 52 patients with ALL were diagnosed and treated at the Chaim Sheba Medical Center. Using standard cell markers to subtype the blasts, 49 of the patients could be classified: 16 were found to be T-cell ALL, 10 common ALL, five null ALL, four pre-B and 14 were partially characterized as non-B, non-T. Analysis of the series revealed two distinctive features: high prevalance (30%) of T-cell ALL among both Jews and Arabs and a high proportion, two-thirds, of high risk patients due to high initial WBC counts, unfavourable age or T-cell characteristics. The minimal incidence of ALL among the Gaza Strip Arab children during the study period is 4: 100,000, which is close to the incidence in the Western world. During previous years the leukemia incidence in the Gaza Strip was very low while the most common lymphatic malignancies were Burkitt tumor and other non-Hodgkin lymphomas.
AB - During the period from 1978 to 1981, 52 patients with ALL were diagnosed and treated at the Chaim Sheba Medical Center. Using standard cell markers to subtype the blasts, 49 of the patients could be classified: 16 were found to be T-cell ALL, 10 common ALL, five null ALL, four pre-B and 14 were partially characterized as non-B, non-T. Analysis of the series revealed two distinctive features: high prevalance (30%) of T-cell ALL among both Jews and Arabs and a high proportion, two-thirds, of high risk patients due to high initial WBC counts, unfavourable age or T-cell characteristics. The minimal incidence of ALL among the Gaza Strip Arab children during the study period is 4: 100,000, which is close to the incidence in the Western world. During previous years the leukemia incidence in the Gaza Strip was very low while the most common lymphatic malignancies were Burkitt tumor and other non-Hodgkin lymphomas.
KW - ALL
KW - effect of environment on lymphatic malignancies
KW - subtypes of ALL
UR - http://www.scopus.com/inward/record.url?scp=0020454433&partnerID=8YFLogxK
U2 - 10.1016/0145-2126(82)90083-2
DO - 10.1016/0145-2126(82)90083-2
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AN - SCOPUS:0020454433
SN - 0145-2126
VL - 6
SP - 669
EP - 673
JO - Leukemia Research
JF - Leukemia Research
IS - 5
ER -
