TY - JOUR
T1 - Acute Kidney Injury and Hair-Straightening Products
T2 - A Case Series
AU - Bnaya, Alon
AU - Abu-Amer, Nabil
AU - Beckerman, Pazit
AU - Volkov, Alexander
AU - Cohen-Hagai, Keren
AU - Greenberg, Meidad
AU - Ben-chetrit, Sydney
AU - Ben Tikva Kagan, Kim
AU - Goldman, Shira
AU - Navarro, Hadar Agmon
AU - Sneineh, Marwan Abu
AU - Rozen-Zvi, Benaya
AU - Borovitz, Yael
AU - Tobar, Ana
AU - Yanay, Noa Berar
AU - Biton, Ray
AU - Angel-Korman, Avital
AU - Rappoport, Vladimir
AU - Leiba, Adi
AU - Bathish, Younes
AU - Farber, Evgeni
AU - Kaidar-Ronat, Maital
AU - Schreiber, Letizia
AU - Shashar, Moshe
AU - Kazarski, Raisa
AU - Chernin, Gil
AU - Itzkowitz, Eyal
AU - Atrash, Jawad
AU - Iaina, Nomy Levin
AU - Efrati, Shai
AU - Nizri, Elad
AU - Lurie, Yael
AU - Ben Itzhak, Ofer
AU - Assady, Suheir
AU - Kenig-Kozlovsky, Yael
AU - Shavit, Linda
N1 - Publisher Copyright:
© 2023 National Kidney Foundation, Inc.
PY - 2023/7
Y1 - 2023/7
N2 - Rationale & Objective: Keratin-based hair-straightening treatment is a popular hair-styling method. The majority of keratin-based hair-straightening products in Israel contain glycolic acid derivatives, which are considered safe when used topically. Systemic absorption of these products is possible, and anecdotal reports have described kidney toxicity associated with their use. We report a series of cases of severe acute kidney injury (AKI) following use of hair-straightening treatment in Israel during the past several years. Study Design: Case series. Setting & Participants: We retrospectively identified 26 patients from 14 medical centers in Israel who experienced severe AKI and reported prior treatment with hair-straightening products in 2019-2022. Findings: The 26 patients described had a median age of 28.5 (range, 14-58) years and experienced severe AKI following a hair-straightening procedure. The most common symptoms at presentation were nausea, vomiting, and abdominal pain. Scalp rash was noted in 10 (38%) patients. Two patients experienced a recurrent episode of AKI following a repeat hair-straightening treatment. Seven patients underwent kidney biopsies, which demonstrated intratubular calcium oxalate deposition in 6 and microcalcification in tubular cells in 1. In all biopsies, signs of acute tubular injury were present, and an interstitial infiltrate was noted in 4 cases. Three patients required temporary dialysis. Limitations: Retrospective uncontrolled study, small number of kidney biopsies. Conclusions: This series describes cases of AKI with prior exposure to hair-straightening treatments. Acute oxalate nephropathy was the dominant finding on kidney biopsies, which may be related to absorption of glycolic acid derivatives and their metabolism to oxalate. This case series suggests a potential underrecognized cause of AKI in the young healthy population. Further studies are needed to confirm this association and to assess the extent of this phenomenon as well as its pathogenesis.
AB - Rationale & Objective: Keratin-based hair-straightening treatment is a popular hair-styling method. The majority of keratin-based hair-straightening products in Israel contain glycolic acid derivatives, which are considered safe when used topically. Systemic absorption of these products is possible, and anecdotal reports have described kidney toxicity associated with their use. We report a series of cases of severe acute kidney injury (AKI) following use of hair-straightening treatment in Israel during the past several years. Study Design: Case series. Setting & Participants: We retrospectively identified 26 patients from 14 medical centers in Israel who experienced severe AKI and reported prior treatment with hair-straightening products in 2019-2022. Findings: The 26 patients described had a median age of 28.5 (range, 14-58) years and experienced severe AKI following a hair-straightening procedure. The most common symptoms at presentation were nausea, vomiting, and abdominal pain. Scalp rash was noted in 10 (38%) patients. Two patients experienced a recurrent episode of AKI following a repeat hair-straightening treatment. Seven patients underwent kidney biopsies, which demonstrated intratubular calcium oxalate deposition in 6 and microcalcification in tubular cells in 1. In all biopsies, signs of acute tubular injury were present, and an interstitial infiltrate was noted in 4 cases. Three patients required temporary dialysis. Limitations: Retrospective uncontrolled study, small number of kidney biopsies. Conclusions: This series describes cases of AKI with prior exposure to hair-straightening treatments. Acute oxalate nephropathy was the dominant finding on kidney biopsies, which may be related to absorption of glycolic acid derivatives and their metabolism to oxalate. This case series suggests a potential underrecognized cause of AKI in the young healthy population. Further studies are needed to confirm this association and to assess the extent of this phenomenon as well as its pathogenesis.
KW - Acute kidney injury (AKI)
KW - acute oxalate nephropathy
KW - adverse reaction
KW - calcium oxalate
KW - case series
KW - formaldehyde
KW - glycolic acid derivatives
KW - hair straightening
KW - nephrotoxic AKI
KW - product safety
KW - renal biopsy
KW - renal toxicity
UR - http://www.scopus.com/inward/record.url?scp=85149822662&partnerID=8YFLogxK
U2 - 10.1053/j.ajkd.2022.11.016
DO - 10.1053/j.ajkd.2022.11.016
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C2 - 36610611
AN - SCOPUS:85149822662
SN - 0272-6386
VL - 82
SP - 43-52.e1
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -