Acute hemodynamic effects of nisoldipine in young hypertensive patients

R. Zimlichman*, D. Zilberman, B. Gold

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The hemodynamic effects of oral nisoldiopine in 12 hypertensive patients aged 35-55 years were determined using the impedance cardiography method. Hemodynamic measurements were performed at hourly intervals before and following ingestion of the medication. Nisoldipine significantly decreased systolic and diastolic blood pressure, with a slight increase in heart rate. Stroke volume did not change significantly following the medication. Total peripheral resistance decreased gradually reaching its lowest values 2 h after ingestion of nisoldipine. We conclude that nisoldipine is a potent oral antihypertensive agent that induces peripheral vasodilatation without decrease in cardiac output.

Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalIsrael Journal of Medical Sciences
Issue number5
StatePublished - 1995
Externally publishedYes


  • Hemodynamics
  • Hypertension
  • Nisoldipine


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