Acute hemodynamic and arrhy thmogenic effects of high‐dose intravenous salbutamol in patients with chronic left ventricular dysfunction

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Abstract

The short‐term hemodynamic and possible arrhythmogenic effects of intravenous salbutamol at a dose of 30 or 60 m̈g/min were evaluated in 14 patients with severe chronic left ventricular dysfunction using equilibrium radionuclide angiocardiography and electrocardiographic monitoring. Salbutamol infusions at a dose of 30 m̈g/min did not cause significant hemodynamic changes; however, at a dose of 60 m̈g/min there was a significant increase in stroke volume, cardiac output, and left ventricular ejection fraction. Heart rate increased significantly while systemic peripheral resistance decreased significantly. Two patients developed ventricular premature beats and another two supraventricular tachycardia, but none were associated with adverse consequences. Thus, high‐dose intravenous salbutamol is effective and safe, and may be used in the acute management of patients with poor left ventricular function.

Original languageEnglish
Pages (from-to)468-472
Number of pages5
JournalClinical Cardiology
Volume13
Issue number7
DOIs
StatePublished - Jul 1990

Keywords

  • arrhythmia
  • left ventricular dysfunction
  • salbutamol

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