Acute effect of percutaneous MitraClip therapy in patients with haemodynamic decompensation

Simon Biner, Robert J. Siegel, Ted Feldman, Asim M. Rafique, Alfredo Trento, Patrick Whitlow, Jason Rogers, Marc Moon, Brian Lindman, Alan Zajarias, Donald Glower, Saibal Kar

Research output: Contribution to journalArticlepeer-review


Aims To evaluate the haemodynamic effect of acute procedural success (APS) after MitraClip therapy in patients with haemodynamic decompensation.Methods and resultsOf 107 patients, 79 achieved APS after MitraClip implantation. The increase in cardiac index (CI) was primarily detected in patients with a low baseline CI (2.0 ± 0.5 to 2.5 ± 5 L/min/m2, P < 0.001). There was a decrease in left ventricular end-diastolic pressure (LVEDP) (20 ± 5 to 13 ± 5 mmHg, P = 0.002) and mean pulmonary capillary wedge pressure (PCWPm) (20 ± 4 to 16 ± 5 mmHg, P = 0.001) in patients with values >15 mmHg at baseline, and a decrease in mean pulmonary artery systolic (PAPm) (36 ± 4 to 29 ± 7 mmHg P = 0.003) in those with values >30 mmHg before the MitraClip procedure. Patients with decompensation compared with patients with compensation experienced significant reduction in LVEDP (8.3 ± 11.9 mmHg vs. 0.2 ± 4.5 mmHg, P = 0.009), a reduction in PCWPm (3.5 ± 5.6 mmHg vs. 1.9 ± 4.7 mmHg, P < 0.001), and a reduction in PAPm (8 ± 9 mmHg vs. 3 ± 6 mmHg, P < 0.001).ConclusionThe favourable haemodynamic effects of MitraClip therapy on CI were primarily detected in patients with low CI before the procedure, and improvements in left-sided filling pressure and PAP were primarily seen in those with elevated values at baseline.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalEuropean Journal of Heart Failure
Issue number8
StatePublished - Aug 2012
Externally publishedYes


  • Haemodynamics
  • MitraClip
  • Mitral regurgitation


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