TY - JOUR
T1 - Acute effect of percutaneous MitraClip therapy in patients with haemodynamic decompensation
AU - Biner, Simon
AU - Siegel, Robert J.
AU - Feldman, Ted
AU - Rafique, Asim M.
AU - Trento, Alfredo
AU - Whitlow, Patrick
AU - Rogers, Jason
AU - Moon, Marc
AU - Lindman, Brian
AU - Zajarias, Alan
AU - Glower, Donald
AU - Kar, Saibal
PY - 2012/8
Y1 - 2012/8
N2 - Aims To evaluate the haemodynamic effect of acute procedural success (APS) after MitraClip therapy in patients with haemodynamic decompensation.Methods and resultsOf 107 patients, 79 achieved APS after MitraClip implantation. The increase in cardiac index (CI) was primarily detected in patients with a low baseline CI (2.0 ± 0.5 to 2.5 ± 5 L/min/m2, P < 0.001). There was a decrease in left ventricular end-diastolic pressure (LVEDP) (20 ± 5 to 13 ± 5 mmHg, P = 0.002) and mean pulmonary capillary wedge pressure (PCWPm) (20 ± 4 to 16 ± 5 mmHg, P = 0.001) in patients with values >15 mmHg at baseline, and a decrease in mean pulmonary artery systolic (PAPm) (36 ± 4 to 29 ± 7 mmHg P = 0.003) in those with values >30 mmHg before the MitraClip procedure. Patients with decompensation compared with patients with compensation experienced significant reduction in LVEDP (8.3 ± 11.9 mmHg vs. 0.2 ± 4.5 mmHg, P = 0.009), a reduction in PCWPm (3.5 ± 5.6 mmHg vs. 1.9 ± 4.7 mmHg, P < 0.001), and a reduction in PAPm (8 ± 9 mmHg vs. 3 ± 6 mmHg, P < 0.001).ConclusionThe favourable haemodynamic effects of MitraClip therapy on CI were primarily detected in patients with low CI before the procedure, and improvements in left-sided filling pressure and PAP were primarily seen in those with elevated values at baseline.
AB - Aims To evaluate the haemodynamic effect of acute procedural success (APS) after MitraClip therapy in patients with haemodynamic decompensation.Methods and resultsOf 107 patients, 79 achieved APS after MitraClip implantation. The increase in cardiac index (CI) was primarily detected in patients with a low baseline CI (2.0 ± 0.5 to 2.5 ± 5 L/min/m2, P < 0.001). There was a decrease in left ventricular end-diastolic pressure (LVEDP) (20 ± 5 to 13 ± 5 mmHg, P = 0.002) and mean pulmonary capillary wedge pressure (PCWPm) (20 ± 4 to 16 ± 5 mmHg, P = 0.001) in patients with values >15 mmHg at baseline, and a decrease in mean pulmonary artery systolic (PAPm) (36 ± 4 to 29 ± 7 mmHg P = 0.003) in those with values >30 mmHg before the MitraClip procedure. Patients with decompensation compared with patients with compensation experienced significant reduction in LVEDP (8.3 ± 11.9 mmHg vs. 0.2 ± 4.5 mmHg, P = 0.009), a reduction in PCWPm (3.5 ± 5.6 mmHg vs. 1.9 ± 4.7 mmHg, P < 0.001), and a reduction in PAPm (8 ± 9 mmHg vs. 3 ± 6 mmHg, P < 0.001).ConclusionThe favourable haemodynamic effects of MitraClip therapy on CI were primarily detected in patients with low CI before the procedure, and improvements in left-sided filling pressure and PAP were primarily seen in those with elevated values at baseline.
KW - Haemodynamics
KW - MitraClip
KW - Mitral regurgitation
UR - http://www.scopus.com/inward/record.url?scp=84864446462&partnerID=8YFLogxK
U2 - 10.1093/eurjhf/hfs069
DO - 10.1093/eurjhf/hfs069
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C2 - 22588322
AN - SCOPUS:84864446462
VL - 14
SP - 939
EP - 945
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 8
ER -