TY - JOUR
T1 - Acute disseminated encephalomyelitis
T2 - current knowledge and open questions
AU - Steiner, Israel
AU - Kennedy, Peter G.E.
N1 - Publisher Copyright:
© 2015, Journal of NeuroVirology, Inc.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Acute disseminated encephalomyelitis (ADEM) is usually an acute, multi-focal, and monophasic immune-mediated disease of the central nervous system. The disorder is mainly a condition of the pediatric age group, but neurologists are also involved in the management of adult patients. The lack of defined diagnostic criteria for ADEM underlies the limited understanding of its epidemiology, etiology, pathogenesis, course, prognosis, therapy, as well as the association with, and distinction from, multiple sclerosis. The present review summarizes current knowledge and outlines unanswered questions the answers to which should be eventually provided through a synergistic combination of clinical and basic research.
AB - Acute disseminated encephalomyelitis (ADEM) is usually an acute, multi-focal, and monophasic immune-mediated disease of the central nervous system. The disorder is mainly a condition of the pediatric age group, but neurologists are also involved in the management of adult patients. The lack of defined diagnostic criteria for ADEM underlies the limited understanding of its epidemiology, etiology, pathogenesis, course, prognosis, therapy, as well as the association with, and distinction from, multiple sclerosis. The present review summarizes current knowledge and outlines unanswered questions the answers to which should be eventually provided through a synergistic combination of clinical and basic research.
KW - Acute disseminated encephalomyelitis
KW - Infection
KW - Multiple sclerosis
KW - Post infection
KW - Viruses
UR - http://www.scopus.com/inward/record.url?scp=84945485883&partnerID=8YFLogxK
U2 - 10.1007/s13365-015-0353-z
DO - 10.1007/s13365-015-0353-z
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C2 - 26037112
AN - SCOPUS:84945485883
SN - 1355-0284
VL - 21
SP - 473
EP - 479
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
IS - 5
ER -