Acute disseminated encephalomyelitis: current knowledge and open questions

Israel Steiner*, Peter G.E. Kennedy

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Acute disseminated encephalomyelitis (ADEM) is usually an acute, multi-focal, and monophasic immune-mediated disease of the central nervous system. The disorder is mainly a condition of the pediatric age group, but neurologists are also involved in the management of adult patients. The lack of defined diagnostic criteria for ADEM underlies the limited understanding of its epidemiology, etiology, pathogenesis, course, prognosis, therapy, as well as the association with, and distinction from, multiple sclerosis. The present review summarizes current knowledge and outlines unanswered questions the answers to which should be eventually provided through a synergistic combination of clinical and basic research.

Original languageEnglish
Pages (from-to)473-479
Number of pages7
JournalJournal of NeuroVirology
Issue number5
StatePublished - 1 Oct 2015
Externally publishedYes


  • Acute disseminated encephalomyelitis
  • Infection
  • Multiple sclerosis
  • Post infection
  • Viruses


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