@article{c13d57fd18834c12921cab12ab747750,
title = "Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease",
abstract = "The effect of prior incubation with a single concentration of isoproterenol (10-4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.",
author = "Gerald Oppenheim and Jacob Mintzer and Yitzhak Halperin and Rami Eliakim and Jochanan Stessman and Ebstein, \{Richard P.\}",
note = "Funding Information: This work was supportedb y grants from the Chief Scientist's Office, Israel Ministry of Health; the HermanG oldmanF oundation,N ew York, and the Pollinger Foundation,W ashington.",
year = "1984",
month = oct,
day = "22",
doi = "10.1016/0024-3205(84)90277-7",
language = "אנגלית",
volume = "35",
pages = "1795--1802",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "17",
}