Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease

Gerald Oppenheim, Jacob Mintzer, Yitzhak Halperin, Rami Eliakim, Jochanan Stessman, Richard P. Ebstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of prior incubation with a single concentration of isoproterenol (10-4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.

Original languageEnglish
Pages (from-to)1795-1802
Number of pages8
JournalLife Sciences
Volume35
Issue number17
DOIs
StatePublished - 22 Oct 1984
Externally publishedYes

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