Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease

Gerald Oppenheim; Jacob Mintzer; Yitzhak Halperin; Rami Eliakim; Jochanan Stessman; Richard P. Ebstein

doi:10.1016/0024-3205(84)90277-7

Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease

Gerald Oppenheim, Jacob Mintzer, Yitzhak Halperin, Rami Eliakim, Jochanan Stessman, Richard P. Ebstein^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of prior incubation with a single concentration of isoproterenol (10^-4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.

Original language	English
Pages (from-to)	1795-1802
Number of pages	8
Journal	Life Sciences
Volume	35
Issue number	17
DOIs	https://doi.org/10.1016/0024-3205(84)90277-7
State	Published - 22 Oct 1984
Externally published	Yes

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10.1016/0024-3205(84)90277-7

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@article{c13d57fd18834c12921cab12ab747750,

title = "Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease",

abstract = "The effect of prior incubation with a single concentration of isoproterenol (10-4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.",

author = "Gerald Oppenheim and Jacob Mintzer and Yitzhak Halperin and Rami Eliakim and Jochanan Stessman and Ebstein, {Richard P.}",

note = "Funding Information: This work was supportedb y grants from the Chief Scientist's Office, Israel Ministry of Health; the HermanG oldmanF oundation,N ew York, and the Pollinger Foundation,W ashington.",

year = "1984",

month = oct,

day = "22",

doi = "10.1016/0024-3205(84)90277-7",

language = "אנגלית",

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TY - JOUR

T1 - Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease

AU - Oppenheim, Gerald

AU - Mintzer, Jacob

AU - Halperin, Yitzhak

AU - Eliakim, Rami

AU - Stessman, Jochanan

AU - Ebstein, Richard P.

N1 - Funding Information: This work was supportedb y grants from the Chief Scientist's Office, Israel Ministry of Health; the HermanG oldmanF oundation,N ew York, and the Pollinger Foundation,W ashington.

PY - 1984/10/22

Y1 - 1984/10/22

N2 - The effect of prior incubation with a single concentration of isoproterenol (10-4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.

AB - The effect of prior incubation with a single concentration of isoproterenol (10-4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.

UR - http://www.scopus.com/inward/record.url?scp=0021163880&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(84)90277-7

DO - 10.1016/0024-3205(84)90277-7

M3 - מאמר

AN - SCOPUS:0021163880

VL - 35

SP - 1795

EP - 1802

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 17

ER -

Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease

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