Abstract
Memory T cells producing interferon (IFN)γ and expressing very late antigen-1 (VLA-1) integrin collagen receptors are found in carotid atherosclerotic plaques, suggesting their involvement in coronary artery disease (CAD) as well. To determine the role of VLA-1+ T cells in CAD percent of CD3+ T cells binding monoclonal antibodies (mAb) to VLA-1 in peripheral blood (PB), and in coronary plaque material aspirated during coronary arterography and arterial blood, were analyzed in a cohort of 117 patients with CAD and 34 controls without CAD. % VLA-1+ T cells in PB was 0.63. ±. 0.09% in controls compared to 0.96. ±. 0.95% in patients with CAD (p<. 0.009). The increase was due to a marked elevation of % VLA-1+ T cells in stable CAD (1.6. ±. 0.27%) whereas %VLA-1+ T cells during acute coronary syndromes (ACS) and in patients with ischemia by thalium SPECT scan had significantly lower levels. %VLA-1+ T cells in coronary artery plaque material aspirated during therapeutic angiography in patients with ACS was significantly higher than in arterial blood (1.39. ±. 0.96% vs 0.75. ±. 0.84%, p<. 0.035, n=3). Thus, % VLA-1+ T cells increases in the PB during stable CAD but decreases in ACS. The finding of their enrichment in coronary blood containing atherosclerotic plaque aspirates suggests that a shift of VLA-1+ T cells from blood to atherosclerotic plaques may play a role in plaque instability in patients with ACS.
Original language | English |
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Pages (from-to) | 302-307 |
Number of pages | 6 |
Journal | Immunobiology |
Volume | 219 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2014 |
Keywords
- Alpha1beta1 integrin
- Atherosclerosis
- Coronary artery disease
- Integrin
- T cells
- VLA-1