Acute changes in endometrial thickness after aspiration of functional ovarian cysts

Ariel Weissman*, Amihai Barash, Moshe Manor, Alon Ben-Arie, Irit Granot, Zeev Shoham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective: To evaluate the influence of aspiration of functional ovarian cysts on endometrial thickness. Design: Prospective study. Setting: An IVF Unit of an academic medical center. Patient(s): Twenty-two patients from our IVF program, in whom administration of a gonadotropin-releasing hormone agonist preparation in the 'long protocol' failed to induce pituitary desensitization, as evidenced by a serum E2 concentration of >55 pg/mL and the presence of an ovarian cyst of >20 mm in diameter. Intervention(s): Transvaginal ultrasonographic-guided cyst aspiration was performed, and 2 days later, serum E2 concentration and endometrial thickness were reassessed. Main Outcome Measure(s): The values of serum E2 concentration and endometrial thickness before and after cyst aspiration were compared. Result(s): Two days after ovarian cyst aspiration, the serum E2 concentration dropped from a mean (±SD) of 203 ± 93 to 37 ± 34 pg/mL. The mean (±SD) endometrial thickness was 9.6 ± 2.0 mm before cyst aspiration and decreased to 5.9 ± 2.4 mm after the procedure. Conclusion(s): Within 48 hours after ovarian cyst aspiration, a significant reduction in endometrial thickness occurs concomitant with a sharp decline in serum E2 levels. The phenomenon of acute reduction in endometrial thickness in response to acute estrogen withdrawal has not been described previously. The exact mechanism and eadometrial component involved in the 'shrinking' process should be further investigated.

Original languageEnglish
Pages (from-to)1142-1144
Number of pages3
JournalFertility and Sterility
Issue number6
StatePublished - Jun 1998
Externally publishedYes


  • Down-regulation
  • Endometrial thickness
  • GnRH-a
  • Ovarian cyst
  • Ultrasonography


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