Acute and chronic complications of type 2 diabetes mellitus in children and adolescents

Orit Pinhas-Hamiel*, Philip Zeitler

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


With the increase in prevalence of type 2 diabetes mellitus in adolescents, a rise in incidence of secondary comorbidities-including hypertension, hyperlipidaemia, nephropathy, and retinopathy-is anticipated. Furthermore, findings of studies in young adults have suggested that the development and progression of clinical complications might be especially rapid when the onset of type 2 diabetes is early, raising the possibility of a serious public-health challenge in the next few decades. To date, reports of the epidemiology and natural history of secondary complications specifically in adolescents with type 2 diabetes have been scarce. Yet, we must begin to understand the extent of the coming challenge. To this end, we have reviewed reports on acute and long-term comorbidities associated with type 2 diabetes in young people and have looked at mounting evidence that this group could be at increased risk for development of early complications.

Original languageEnglish
Pages (from-to)1823-1831
Number of pages9
JournalThe Lancet
Issue number9575
StatePublished - 26 May 2007
Externally publishedYes


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