Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects

Zvi Zemishlany; Michael Davidson; Stacey Jaff; Robert McQueeney

doi:10.1016/0920-9964(91)90056-W

Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects

Zvi Zemishlany^*, Michael Davidson, Stacey Jaff, Robert McQueeney

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Alprazolam has been suggested as an adjuvant to neuroleptic drugs in the treatment of schizophrenic patients. In an attempt to investigate whether alprazolam has an effect on dopaminergic neurotransmission, plasma homovanillic acid concentrations were measured for 24 h following a challenge with 3 mg of alprazolam or placebo in eight healthy subjects. Alprazolam had no effect on plasma homovanillic acid which may suggest that this agent is devoid of activity at the dopaminergic system in normal subjects.

Original language	English
Pages (from-to)	81-83
Number of pages	3
Journal	Schizophrenia Research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/0920-9964(91)90056-W
State	Published - 1991
Externally published	Yes

Keywords

(Schizophrenia)
Alprazolam
Plasma homovanillic acid

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10.1016/0920-9964(91)90056-W

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abstract = "Alprazolam has been suggested as an adjuvant to neuroleptic drugs in the treatment of schizophrenic patients. In an attempt to investigate whether alprazolam has an effect on dopaminergic neurotransmission, plasma homovanillic acid concentrations were measured for 24 h following a challenge with 3 mg of alprazolam or placebo in eight healthy subjects. Alprazolam had no effect on plasma homovanillic acid which may suggest that this agent is devoid of activity at the dopaminergic system in normal subjects.",

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AU - Jaff, Stacey

AU - McQueeney, Robert

PY - 1991

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AB - Alprazolam has been suggested as an adjuvant to neuroleptic drugs in the treatment of schizophrenic patients. In an attempt to investigate whether alprazolam has an effect on dopaminergic neurotransmission, plasma homovanillic acid concentrations were measured for 24 h following a challenge with 3 mg of alprazolam or placebo in eight healthy subjects. Alprazolam had no effect on plasma homovanillic acid which may suggest that this agent is devoid of activity at the dopaminergic system in normal subjects.

KW - (Schizophrenia)

KW - Alprazolam

KW - Plasma homovanillic acid

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Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects

Abstract

Keywords

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