Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer

Leonard Leibovici, Nili Schoenfeld, Henry A. Yehoshua, Rivka Mamet, Erica Rakowsky, Asher Shindel, Abraham Atsmon

Research output: Contribution to journalArticlepeer-review

Abstract

Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.

Original languageEnglish
Pages (from-to)2297-2300
Number of pages4
JournalCancer
Volume62
Issue number11
DOIs
StatePublished - 1 Dec 1988

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