Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer

Leonard Leibovici; Nili Schoenfeld; Henry A. Yehoshua; Rivka Mamet; Erica Rakowsky; Asher Shindel; Abraham Atsmon

doi:10.1002/1097-0142(19881201)62:11<2297::AID-CNCR2820621106>3.0.CO;2-7

Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer

Leonard Leibovici^*, Nili Schoenfeld, Henry A. Yehoshua, Rivka Mamet, Erica Rakowsky, Asher Shindel, Abraham Atsmon

^*Corresponding author for this work

Clinical Departments

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.

Original language	English
Pages (from-to)	2297-2300
Number of pages	4
Journal	Cancer
Volume	62
Issue number	11
DOIs	https://doi.org/10.1002/1097-0142(19881201)62:11<2297::AID-CNCR2820621106>3.0.CO;2-7
State	Published - 1 Dec 1988

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10.1002/1097-0142(19881201)62:11<2297::AID-CNCR2820621106>3.0.CO;2-7

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title = "Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer",

abstract = "Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.",

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AU - Leibovici, Leonard

AU - Schoenfeld, Nili

AU - Yehoshua, Henry A.

AU - Mamet, Rivka

AU - Rakowsky, Erica

AU - Shindel, Asher

AU - Atsmon, Abraham

PY - 1988/12/1

Y1 - 1988/12/1

N2 - Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.

AB - Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.

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JO - Cancer

JF - Cancer

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Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer

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