TY - JOUR
T1 - Activity of deferasirox in Mucorales
T2 - Influences of species and exogenous iron
AU - Lewis, Russell E.
AU - Pongas, Georgios N.
AU - Albert, Nathaniel
AU - Ben-Ami, Ronen
AU - Walsh, Thomas J.
AU - Kontoyiannis, Dimitrios P.
PY - 2011/1
Y1 - 2011/1
N2 - Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.
AB - Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.
UR - http://www.scopus.com/inward/record.url?scp=78650665671&partnerID=8YFLogxK
U2 - 10.1128/AAC.00792-10
DO - 10.1128/AAC.00792-10
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C2 - 20956598
AN - SCOPUS:78650665671
SN - 0066-4804
VL - 55
SP - 411
EP - 413
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -