Activity of cytotoxin P4 from the venom of the cobra snake naja nigricollis on gram-positive bacteria and eukaryotic cell lines

Ute Möllmann; Walter Gutsche; Lydia Maltz; Michael Ovadia

Activity of cytotoxin P₄ from the venom of the cobra snake naja nigricollis on gram-positive bacteria and eukaryotic cell lines

Ute Möllmann^*, Walter Gutsche, Lydia Maltz, Michael Ovadia

^*Corresponding author for this work

School of Zoology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The cytotoxin P₄ from the venom or the cobra snake Naja nigricollis was examined for activity against aerobic gram-positive and gram-negative bacteria, yeasts, fungi and eucaryotic cell lines by determination of minimal inhibitory concentrations (MIC) and IC₅₀ values, respectively. Cytotoxin P₄ exhibits antimicrobial activity against Bacillus subtilis, Micrococcus flavus and Sarcina lutea. Targets in gram-negative bacteria and fungi apparently were not reached. Toxicity against eucaryotic cells is in a narrow range between lethal and tolerable concentrations.

Original language	English
Pages (from-to)	671-673
Number of pages	3
Journal	Arzneimittel-Forschung/Drug Research
Volume	47
Issue number	5
State	Published - 1997

Keywords

Cytotoxins
Naja nigricollis
Snake venoms

Cite this

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title = "Activity of cytotoxin P4 from the venom of the cobra snake naja nigricollis on gram-positive bacteria and eukaryotic cell lines",

abstract = "The cytotoxin P4 from the venom or the cobra snake Naja nigricollis was examined for activity against aerobic gram-positive and gram-negative bacteria, yeasts, fungi and eucaryotic cell lines by determination of minimal inhibitory concentrations (MIC) and IC50 values, respectively. Cytotoxin P4 exhibits antimicrobial activity against Bacillus subtilis, Micrococcus flavus and Sarcina lutea. Targets in gram-negative bacteria and fungi apparently were not reached. Toxicity against eucaryotic cells is in a narrow range between lethal and tolerable concentrations.",

keywords = "Cytotoxins, Naja nigricollis, Snake venoms",

author = "Ute M{\"o}llmann and Walter Gutsche and Lydia Maltz and Michael Ovadia",

year = "1997",

language = "אנגלית",

volume = "47",

pages = "671--673",

journal = "Arzneimittel-Forschung/Drug Research",

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T1 - Activity of cytotoxin P4 from the venom of the cobra snake naja nigricollis on gram-positive bacteria and eukaryotic cell lines

AU - Möllmann, Ute

AU - Gutsche, Walter

AU - Maltz, Lydia

AU - Ovadia, Michael

PY - 1997

Y1 - 1997

N2 - The cytotoxin P4 from the venom or the cobra snake Naja nigricollis was examined for activity against aerobic gram-positive and gram-negative bacteria, yeasts, fungi and eucaryotic cell lines by determination of minimal inhibitory concentrations (MIC) and IC50 values, respectively. Cytotoxin P4 exhibits antimicrobial activity against Bacillus subtilis, Micrococcus flavus and Sarcina lutea. Targets in gram-negative bacteria and fungi apparently were not reached. Toxicity against eucaryotic cells is in a narrow range between lethal and tolerable concentrations.

AB - The cytotoxin P4 from the venom or the cobra snake Naja nigricollis was examined for activity against aerobic gram-positive and gram-negative bacteria, yeasts, fungi and eucaryotic cell lines by determination of minimal inhibitory concentrations (MIC) and IC50 values, respectively. Cytotoxin P4 exhibits antimicrobial activity against Bacillus subtilis, Micrococcus flavus and Sarcina lutea. Targets in gram-negative bacteria and fungi apparently were not reached. Toxicity against eucaryotic cells is in a narrow range between lethal and tolerable concentrations.

KW - Cytotoxins

KW - Naja nigricollis

KW - Snake venoms

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AN - SCOPUS:0031135656

SN - 0004-4172

VL - 47

SP - 671

EP - 673

JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

IS - 5

ER -

Activity of cytotoxin P₄ from the venom of the cobra snake naja nigricollis on gram-positive bacteria and eukaryotic cell lines

Abstract

Keywords

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