Activity of adenosine deaminase and of purine nucleoside phosphorylase in peripheral lymphocytes from patients with acquired immunological disorders

Y. Sidi; P. Boer; I. Pick; J. Pinkhas; O. Sperling

Activity of adenosine deaminase and of purine nucleoside phosphorylase in peripheral lymphocytes from patients with acquired immunological disorders

Y. Sidi, P. Boer, I. Pick, J. Pinkhas, O. Sperling

Clinical Biochemistry

Rogoff-Wellcome Medical Research Institute

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The activity of adenosine deaminase (ADA) and of purine nucleoside phosphorylase (PNP) was determined in the peripheral lymphocytes of patients with diseases associated with acquired partial dysfunction of the immune response. Increased ADA activity was found in patients with Waldenstrom's macroglobulinemia and in some patients with non-Hodgkin's lymphoma. Increased PNP activity was found in patients with non-Hodgkin's lymphoma, whereas decreased PNP activity was found in patients with connective tissue disorders. The alterations found in ADA and PNP activities probably reflect changes in the lymphocyte subpopulations and do not seem to play an etiological role in the pathogenesis of the disturbed immune response.

Original language	English
Pages (from-to)	39-41
Number of pages	3
Journal	Biomedicine Express
Volume	33
Issue number	2
State	Published - 1980

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title = "Activity of adenosine deaminase and of purine nucleoside phosphorylase in peripheral lymphocytes from patients with acquired immunological disorders",

abstract = "The activity of adenosine deaminase (ADA) and of purine nucleoside phosphorylase (PNP) was determined in the peripheral lymphocytes of patients with diseases associated with acquired partial dysfunction of the immune response. Increased ADA activity was found in patients with Waldenstrom's macroglobulinemia and in some patients with non-Hodgkin's lymphoma. Increased PNP activity was found in patients with non-Hodgkin's lymphoma, whereas decreased PNP activity was found in patients with connective tissue disorders. The alterations found in ADA and PNP activities probably reflect changes in the lymphocyte subpopulations and do not seem to play an etiological role in the pathogenesis of the disturbed immune response.",

author = "Y. Sidi and P. Boer and I. Pick and J. Pinkhas and O. Sperling",

year = "1980",

language = "אנגלית",

volume = "33",

pages = "39--41",

journal = "Biomedicine Express",

issn = "0300-0885",

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T1 - Activity of adenosine deaminase and of purine nucleoside phosphorylase in peripheral lymphocytes from patients with acquired immunological disorders

AU - Sidi, Y.

AU - Boer, P.

AU - Pick, I.

AU - Pinkhas, J.

AU - Sperling, O.

PY - 1980

Y1 - 1980

N2 - The activity of adenosine deaminase (ADA) and of purine nucleoside phosphorylase (PNP) was determined in the peripheral lymphocytes of patients with diseases associated with acquired partial dysfunction of the immune response. Increased ADA activity was found in patients with Waldenstrom's macroglobulinemia and in some patients with non-Hodgkin's lymphoma. Increased PNP activity was found in patients with non-Hodgkin's lymphoma, whereas decreased PNP activity was found in patients with connective tissue disorders. The alterations found in ADA and PNP activities probably reflect changes in the lymphocyte subpopulations and do not seem to play an etiological role in the pathogenesis of the disturbed immune response.

AB - The activity of adenosine deaminase (ADA) and of purine nucleoside phosphorylase (PNP) was determined in the peripheral lymphocytes of patients with diseases associated with acquired partial dysfunction of the immune response. Increased ADA activity was found in patients with Waldenstrom's macroglobulinemia and in some patients with non-Hodgkin's lymphoma. Increased PNP activity was found in patients with non-Hodgkin's lymphoma, whereas decreased PNP activity was found in patients with connective tissue disorders. The alterations found in ADA and PNP activities probably reflect changes in the lymphocyte subpopulations and do not seem to play an etiological role in the pathogenesis of the disturbed immune response.

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AN - SCOPUS:0019154750

SN - 0300-0885

VL - 33

SP - 39

EP - 41

JO - Biomedicine Express

JF - Biomedicine Express

IS - 2

ER -

Activity of adenosine deaminase and of purine nucleoside phosphorylase in peripheral lymphocytes from patients with acquired immunological disorders

Abstract

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