Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death

Gordon W. Glazner; Andre Boland; Albert E. Dresse; Douglas E. Brenneman; Illana Gozes; Mark P. Mattson

doi:10.1046/j.1471-4159.1999.0732341.x

Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death

Gordon W. Glazner^*, Andre Boland, Albert E. Dresse, Douglas E. Brenneman, Illana Gozes, Mark P. Mattson

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO₄ and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.

Original language	English
Pages (from-to)	2341-2347
Number of pages	7
Journal	Journal of Neurochemistry
Volume	73
Issue number	6
DOIs	https://doi.org/10.1046/j.1471-4159.1999.0732341.x
State	Published - 1999

Keywords

Activity-dependent neurotrophic factor
Apoptosis
Neurons
Reactive oxygen species
Trophic factor withdrawal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1471-4159.1999.0732341.x

Cite this

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title = "Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death",

abstract = "Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.",

keywords = "Activity-dependent neurotrophic factor, Apoptosis, Neurons, Reactive oxygen species, Trophic factor withdrawal",

author = "Glazner, {Gordon W.} and Andre Boland and Dresse, {Albert E.} and Brenneman, {Douglas E.} and Illana Gozes and Mattson, {Mark P.}",

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AU - Glazner, Gordon W.

AU - Boland, Andre

AU - Dresse, Albert E.

AU - Brenneman, Douglas E.

AU - Gozes, Illana

AU - Mattson, Mark P.

PY - 1999

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N2 - Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.

AB - Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.

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KW - Apoptosis

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KW - Reactive oxygen species

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Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death

Abstract

Keywords

UN SDGs

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