Activity-dependent neuroprotective protein: From gene to drug candidate

Research output: Contribution to journalReview articlepeer-review


Activity-dependent neuroprotective protein (ADNP) is essential for brain formation. The gene encoding ADNP is highly conserved and abundantly expressed in the brain. ADNP contains a homeobox profile and a peptide motif providing neuroprotection against a variety of cytotoxic insults. ADNP mRNA and protein expression responds to brain injury and oscillates as a function of the estrus cycle. The plastic nature of ADNP expression is correlated with brain protection and an association between neuroendocrine regulation and neuroprotection is put forth with ADNP as a focal point. Further understanding of neuroprotective molecules should pave the path to better diagnostics and therapies. In this respect, structure-activity studies have identified a short 8 amino acid peptide in ADNP/NAPVSIPQ (NAP) that provides potent neuroprotection. NAP is currently in clinical development for neuroprotection.

Original languageEnglish
Pages (from-to)146-154
Number of pages9
JournalPharmacology and Therapeutics
Issue number2
StatePublished - May 2007
Externally publishedYes


  • Activity-dependent neuroprotective protein
  • Glial cells
  • Neuroprotection
  • Vasoactive intestinal peptide


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