Activity-Based Approach for Selective Molecular CO2Sensing

Ori Green, Patrick Finkelstein, Miguel A. Rivero-Crespo, Marius D.R. Lutz, Michael K. Bogdos, Michael Burger, Jean Christophe Leroux, Bill Morandi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Carbon dioxide (CO2) impacts every aspect of life, and numerous sensing technologies have been established to detect and monitor this ubiquitous molecule. However, its selective sensing at the molecular level remains an unmet challenge, despite the tremendous potential of such an approach for understanding this molecule's role in complex environments. In this work, we introduce a unique class of selective fluorescent carbon dioxide molecular sensors (CarboSen) that addresses these existing challenges through an activity-based approach. Besides the design, synthesis, and evaluation of these small molecules as CO2 sensors, we demonstrate their utility by tailoring their reactivity and optical properties, allowing their use in a broad spectrum of multidisciplinary applications, including atmospheric sensing, chemical reaction monitoring, enzymology, and live-cell imaging. Collectively, these results showcase the potential of CarboSen sensors as broadly applicable tools to monitor and visualize carbon dioxide across multiple disciplines.

Original languageEnglish
JournalJournal of the American Chemical Society
StateAccepted/In press - 2022
Externally publishedYes


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