Activation of the respiratory burst of guinea pig neutrophils by dicyclohexylcarbodiimide

Adina Aviram*, Irit Aviram

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

DCCD activates the respiratory burst in guinea pig peritoneal neutrophils. The onset of the superoxide producing activity is preceeded by a lag, inversely proportional to the dose of the stimulant and to the temperature. Initial rates of superoxide formation exhibit different dependencies on the concentrations of DCCD and on temperature. Activation of NAD(P)H oxidase is inhibited by preincubation of neutrophils with 2-deoxyglucose and does not require the presence of extra cellular Ca2+.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalFEBS Letters
Volume155
Issue number2
DOIs
StatePublished - 8 May 1983

Keywords

  • Dicyclohexylcarbodiimide
  • Neutrophil
  • Respiratory burst
  • Superoxide

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