Activation of the respiratory burst of guinea pig neutrophils by dicyclohexylcarbodiimide

Adina Aviram; Irit Aviram

doi:10.1016/0014-5793(82)80603-0

Activation of the respiratory burst of guinea pig neutrophils by dicyclohexylcarbodiimide

Adina Aviram^*, Irit Aviram

^*Corresponding author for this work

Biochemistry Molecular Biology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

DCCD activates the respiratory burst in guinea pig peritoneal neutrophils. The onset of the superoxide producing activity is preceeded by a lag, inversely proportional to the dose of the stimulant and to the temperature. Initial rates of superoxide formation exhibit different dependencies on the concentrations of DCCD and on temperature. Activation of NAD(P)H oxidase is inhibited by preincubation of neutrophils with 2-deoxyglucose and does not require the presence of extra cellular Ca²⁺.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	FEBS Letters
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(82)80603-0
State	Published - 8 May 1983

Keywords

Dicyclohexylcarbodiimide
Neutrophil
Respiratory burst
Superoxide

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-5793(82)80603-0

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abstract = "DCCD activates the respiratory burst in guinea pig peritoneal neutrophils. The onset of the superoxide producing activity is preceeded by a lag, inversely proportional to the dose of the stimulant and to the temperature. Initial rates of superoxide formation exhibit different dependencies on the concentrations of DCCD and on temperature. Activation of NAD(P)H oxidase is inhibited by preincubation of neutrophils with 2-deoxyglucose and does not require the presence of extra cellular Ca2+.",

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AU - Aviram, Irit

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N2 - DCCD activates the respiratory burst in guinea pig peritoneal neutrophils. The onset of the superoxide producing activity is preceeded by a lag, inversely proportional to the dose of the stimulant and to the temperature. Initial rates of superoxide formation exhibit different dependencies on the concentrations of DCCD and on temperature. Activation of NAD(P)H oxidase is inhibited by preincubation of neutrophils with 2-deoxyglucose and does not require the presence of extra cellular Ca2+.

AB - DCCD activates the respiratory burst in guinea pig peritoneal neutrophils. The onset of the superoxide producing activity is preceeded by a lag, inversely proportional to the dose of the stimulant and to the temperature. Initial rates of superoxide formation exhibit different dependencies on the concentrations of DCCD and on temperature. Activation of NAD(P)H oxidase is inhibited by preincubation of neutrophils with 2-deoxyglucose and does not require the presence of extra cellular Ca2+.

KW - Dicyclohexylcarbodiimide

KW - Neutrophil

KW - Respiratory burst

KW - Superoxide

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Activation of the respiratory burst of guinea pig neutrophils by dicyclohexylcarbodiimide

Abstract

Keywords

UN SDGs

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