Activation of the amyloid cascade by intracerebroventricular injection of the protease inhibitor phosphoramidon

Yotam Nisemblat, Haim Belinson, Iftach Dolev, Daniel M. Michaelson

Research output: Contribution to journalArticlepeer-review

Abstract

We presently investigated the pathological effects of prolonged inhibition of brain β-amyloid (Aβ) degradation in vivo. The results obtained revealed that intracerebroventricular injection of the protease inhibitor phosphoramidon into wild-type mice for up to a month elevated the soluble and deposited brain Aβ levels and concomitantly induced the neurodegeneration of distinct hippocampal neurons as well as neuroinflammation. These findings reproduce pathological effects associated with the initial stages of the amyloid cascade and provide a novel model system for studying their underlying mechanisms.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalNeurodegenerative Diseases
Volume5
Issue number3-4
DOIs
StatePublished - Mar 2008

Keywords

  • Amyloid cascade
  • Neprilysin
  • Phosphoramidon
  • β-Amyloid

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