@article{04abeaeb197043e3a66d62407bba35ab,
title = "Activation of Mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent",
abstract = "The interaction of GnRH with its cognate receptor (GnRHR) in pituitary gonadotropes includes activation of Gq/G11 and phospholipase Cβ (PLCβ), which generates the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which are required for Ca2+ mobilization and PKC isoforms activation. Activation of PKC in pituitary gonadotropes leads to the activation of the major members of the mitogen-activated protein kinase superfamily (MAPK), namely: extracellular signal-regulated kinase (ERK), jun-N-terminal Kinase (JNK) and p38MAPK. The above pathways mediate GnRH-induced gonadotropin release and synthesis. Here we summarise the diverse mechanisms utilized by GnRH to activate the MAPK members and show that they depend on {"}cell-context{"}.",
keywords = "ERK, GnRH, GnRH receptor, JNK, PKC, Pituitary cells, Prostate cancer cells, p38",
author = "Masha Dobkin-Bekman and Michal Naidich and Pawson, {Adam J.} and Millar, {Robert P.} and Rony Seger and Zvi Naor",
note = "Funding Information: We thank Drs. S. Shacham, D. Harris, D. Bonfil, O. Benard and S. Kraus and Prof. N. Stern for their interest and help during the study. The studies were supported by The Israel Science Foundation (Grant No. 221/05).",
year = "2006",
month = jun,
day = "27",
doi = "10.1016/j.mce.2006.03.035",
language = "אנגלית",
volume = "252",
pages = "184--190",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "1-2",
}
