TY - JOUR
T1 - Activation of dopaminergic neurotransmission in the medial prefrontal cortex by N-methyl-D-aspartate stimulation of the ventral hippocampus in rats
AU - Peleg-Raibstein, D.
AU - Pezze, M. A.
AU - Ferger, B.
AU - Zhang, W. N.
AU - Murphy, C. A.
AU - Feldon, J.
AU - Bast, T.
N1 - Funding Information:
Aspects of this work have been published in preliminary form (Bast T, Zhang W-N, Ferger B, Feldon J (2002) FENS Abstr Vol 1:175.3; Peleg D, Pezze MA, Ferger B, Murphy CA, Feldon J, Bast T (2003) Monitoring molecules in neuroscience. Proceedings of the 10 th International Conference on In Vivo Methods. Stockholm: Karolinska University Press, pp 332–334). The support of the technical and animal-care staff of the Laboratory of Behavioral Neurobiology is gratefully acknowledged. Special thanks are due to Liz Weber, for histological preparations, to Peter Schmid, for setup and maintenance of computerized systems, to Andreas Leng, for frequent help and advice concerning HPLC methods, to Gael Hedou, for introducing T.B. to micropunching, and to Ben Yee for statistical advice. This work has been supported by grants from the ETH Zürich and the Swiss National Science Foundation. T.B. is currently employed on an MRC program grant held by Professor Richard Morris, Edinburgh. M.A.P. is recipient of a Marie-Curie Fellowship.
PY - 2005
Y1 - 2005
N2 - Many behavioral functions - including sensorimotor, attentional, memory, and emotional processes - have been associated with hippocampal processes and with dopamine transmission in the medial prefrontal cortex (mPFC). This suggests a functional interaction between hippocampus and prefrontal dopamine. The anatomical substrate for such an interaction is the intimate interconnection between the ventral hippocampus and the dopamine innervation of the mPFC. The present study yielded direct neurochemical evidence for an interaction between ventral hippocampus and prefrontal dopamine transmission in rats by demonstrating that subconvulsive stimulation of the ventral hippocampus with N-methyl-d-aspartate (NMDA; 0.5 μg/side) activates dopamine transmission in the mPFC. Postmortem measurements revealed that bilateral NMDA stimulation of the ventral hippocampus, resulting in locomotor hyperactivity, increased the homovanillic acid/dopamine ratio, an index of dopamine transmission, in the mPFC; indices of dopamine transmission in any of five additionally examined forebrain regions (amygdala, nucleus accumbens shell/core, lateral prefrontal cortex, caudate putamen) were unaltered. In vivo microdialysis measurements in freely moving rats corroborated the suggested activation of prefrontal dopamine transmission by demonstrating that unilateral NMDA stimulation of the ventral hippocampus increased extracellular dopamine in the ipsilateral mPFC. The suggested influence of the ventral hippocampus on prefrontal dopamine may be an important mechanism for hippocampo-prefrontal interactions in normal behavioral processes. Moreover, it indicates that aberrant hippocampal activity, as found in neuropsychiatric diseases, such as schizophrenia and mood disorders, may contribute to disruption of certain cognitive and emotional functions which are extremely sensitive to imbalanced prefrontal dopamine transmission.
AB - Many behavioral functions - including sensorimotor, attentional, memory, and emotional processes - have been associated with hippocampal processes and with dopamine transmission in the medial prefrontal cortex (mPFC). This suggests a functional interaction between hippocampus and prefrontal dopamine. The anatomical substrate for such an interaction is the intimate interconnection between the ventral hippocampus and the dopamine innervation of the mPFC. The present study yielded direct neurochemical evidence for an interaction between ventral hippocampus and prefrontal dopamine transmission in rats by demonstrating that subconvulsive stimulation of the ventral hippocampus with N-methyl-d-aspartate (NMDA; 0.5 μg/side) activates dopamine transmission in the mPFC. Postmortem measurements revealed that bilateral NMDA stimulation of the ventral hippocampus, resulting in locomotor hyperactivity, increased the homovanillic acid/dopamine ratio, an index of dopamine transmission, in the mPFC; indices of dopamine transmission in any of five additionally examined forebrain regions (amygdala, nucleus accumbens shell/core, lateral prefrontal cortex, caudate putamen) were unaltered. In vivo microdialysis measurements in freely moving rats corroborated the suggested activation of prefrontal dopamine transmission by demonstrating that unilateral NMDA stimulation of the ventral hippocampus increased extracellular dopamine in the ipsilateral mPFC. The suggested influence of the ventral hippocampus on prefrontal dopamine may be an important mechanism for hippocampo-prefrontal interactions in normal behavioral processes. Moreover, it indicates that aberrant hippocampal activity, as found in neuropsychiatric diseases, such as schizophrenia and mood disorders, may contribute to disruption of certain cognitive and emotional functions which are extremely sensitive to imbalanced prefrontal dopamine transmission.
KW - Dopamine
KW - Functional interaction
KW - In vivo microdialysis
KW - Metabolites
KW - N-methyl-D-aspartate
KW - Postmortem neurochemistry
UR - http://www.scopus.com/inward/record.url?scp=15044342008&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2004.12.016
DO - 10.1016/j.neuroscience.2004.12.016
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C2 - 15780480
AN - SCOPUS:15044342008
SN - 0306-4522
VL - 132
SP - 219
EP - 232
JO - Neuroscience
JF - Neuroscience
IS - 1
ER -