Abstract
Contrary to resting cells, neutrophils stimulated with concanavalin A resist inhibition by bifunctional N-hydroxysuccinimide esters. Con A prestimulated, cross-linker-treated cells released superoxide upon restimulation with PMA but did not respond to chemotactic peptides. Although rates of PMA-elicited NADPH oxidase activity were lowered by the treatment, the activation parameters, namely lag times of the reaction, were not altered. The protection by Con A against blockade by cross-linkers developed concomitantly to the activation of NADPH oxidase and indicated redistribution of cross-linker-susceptible cellular components responsible for activation with PMA. The identity of these components is discussed.
Original language | English |
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Pages (from-to) | 233-242 |
Number of pages | 10 |
Journal | Inflammation |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1986 |