Activation-dependent redistribution of cellular components alters susceptibility of human neutrophils to cross-linking agents

Irit Aviram, Michaela Sharabani

Research output: Contribution to journalArticlepeer-review

Abstract

Contrary to resting cells, neutrophils stimulated with concanavalin A resist inhibition by bifunctional N-hydroxysuccinimide esters. Con A prestimulated, cross-linker-treated cells released superoxide upon restimulation with PMA but did not respond to chemotactic peptides. Although rates of PMA-elicited NADPH oxidase activity were lowered by the treatment, the activation parameters, namely lag times of the reaction, were not altered. The protection by Con A against blockade by cross-linkers developed concomitantly to the activation of NADPH oxidase and indicated redistribution of cross-linker-susceptible cellular components responsible for activation with PMA. The identity of these components is discussed.

Original languageEnglish
Pages (from-to)233-242
Number of pages10
JournalInflammation
Volume10
Issue number3
DOIs
StatePublished - Sep 1986

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