Action-locked Neural Responses in Auditory Cortex to Self-generated Sounds

Daniel Reznik, Noa Guttman, Batel Buaron, Elana Zion-Golumbic*, Roy Mukamel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Sensory perception is a product of interactions between the internal state of an organism and the physical attributes of a stimulus. It has been shown across the animal kingdom that perception and sensory-evoked physiological responses are modulated depending on whether or not the stimulus is the consequence of voluntary actions. These phenomena are often attributed to motor signals sent to relevant sensory regions that convey information about upcoming sensory consequences. However, the neurophysiological signature of action-locked modulations in sensory cortex, and their relationship with perception, is still unclear. In the current study, we recorded neurophysiological (using Magnetoencephalography) and behavioral responses from 16 healthy subjects performing an auditory detection task of faint tones. Tones were either generated by subjects' voluntary button presses or occurred predictably following a visual cue. By introducing a constant temporal delay between button press/cue and tone delivery, and applying source-level analysis, we decoupled action-locked and auditory-locked activity in auditory cortex. We show action-locked evoked-responses in auditory cortex following sound-triggering actions and preceding sound onset. Such evoked-responses were not found for button-presses that were not coupled with sounds, or sounds delivered following a predictive visual cue. Our results provide evidence for efferent signals in human auditory cortex that are locked to voluntary actions coupled with future auditory consequences.

Original languageEnglish
Pages (from-to)5560-5569
Number of pages10
JournalCerebral Cortex
Volume31
Issue number12
DOIs
StatePublished - 1 Dec 2021

Funding

FundersFunder number
Israeli Presidential Honorary Scholarship for Neuroscience Research
Sagol School of Neuroscience
United States-Israel Binational Science Foundation2015385
Israel Science Foundation2392/19

    Keywords

    • MEG
    • auditory perception
    • motor-sensory interactions
    • voluntary actions

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